TY - JOUR
T1 - Multistate epidemiology of histoplasmosis, united states, 2011–2014
AU - Armstrong, Paige A.
AU - Jackson, Brendan R.
AU - Haselow, Dirk
AU - Fields, Virgie
AU - Ireland, Malia
AU - Austin, Connie
AU - Signs, Kimberly
AU - Fialkowski, Veronica
AU - Patel, Reema
AU - Ellis, Peggy
AU - Iwen, Peter C.
AU - Pedati, Caitlin
AU - Gibbons-Burgener, Suzanne
AU - Anderson, Jannifer
AU - Dobbs, Thomas
AU - Davidson, Sherri
AU - McIntyre, Mary
AU - Warren, Kimberly
AU - Midla, Joanne
AU - Luong, Nhiem
AU - Benedict, Kaitlin
N1 - Funding Information:
This research was supported in part by an appointment to the Applied Epidemiology Fellowship Program administered by CSTE and funded by CDC cooperative agreements (nos. 1U38OT000143-02 and 1U38OT000143-04).
Publisher Copyright:
© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Histoplasmosis is one of the most common mycoses endemic to the United States, but it was reportable in only 10 states during 2016, when a national case definition was approved. To better characterize the epidemiologic features of histoplasmosis, we analyzed deidentified surveillance data for 2011–2014 from the following 12 states: Alabama, Arkansas, Delaware, Illinois, Indiana, Kentucky, Michigan, Minnesota, Mississippi, Nebraska, Pennsylvania, and Wisconsin. We examined epidemiologic and laboratory features and calculated state-spe-cific annual and county-specific mean annual incidence rates. A total of 3,409 cases were reported. Median patient age was 49 (interquartile range 33–61) years, 2,079 (61%) patients were male, 1,273 (57%) patients were hospitalized, and 76 (7%) patients died. Incidence rates varied markedly between and within states. The high hospitalization rate suggests that histoplasmosis surveillance underestimates the true number of cases. Improved surveillance standardization and surveillance by additional states would provide more comprehensive knowledge of histoplasmosis in the United States.
AB - Histoplasmosis is one of the most common mycoses endemic to the United States, but it was reportable in only 10 states during 2016, when a national case definition was approved. To better characterize the epidemiologic features of histoplasmosis, we analyzed deidentified surveillance data for 2011–2014 from the following 12 states: Alabama, Arkansas, Delaware, Illinois, Indiana, Kentucky, Michigan, Minnesota, Mississippi, Nebraska, Pennsylvania, and Wisconsin. We examined epidemiologic and laboratory features and calculated state-spe-cific annual and county-specific mean annual incidence rates. A total of 3,409 cases were reported. Median patient age was 49 (interquartile range 33–61) years, 2,079 (61%) patients were male, 1,273 (57%) patients were hospitalized, and 76 (7%) patients died. Incidence rates varied markedly between and within states. The high hospitalization rate suggests that histoplasmosis surveillance underestimates the true number of cases. Improved surveillance standardization and surveillance by additional states would provide more comprehensive knowledge of histoplasmosis in the United States.
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U2 - 10.3201/eid2403.171258
DO - 10.3201/eid2403.171258
M3 - Article
C2 - 29460731
AN - SCOPUS:85042285581
SN - 1080-6040
VL - 24
SP - 425
EP - 431
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 3
ER -