Multiturn hollow helices: Synthesis and folding of long aromatic oligoamides

Yulong Zhong, Brice Kauffmann, Wenwu Xu, Zhong Lin Lu, Yann Ferrand, Ivan Huc, Xiao Cheng Zeng, Rui Liu, Bing Gong

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aromatic oligoamides adopting helical conformations are synthesized by coupling carboxyl-terminated basic units having two, four, and eight residues to amine-terminated oligomer precursors. Coupling yields show no noticeable reduction with the size of the basic units or the final product. One- and two-dimensional NMR spectroscopy and computational studies demonstrate the reliable helical folding of these oligomers. The X-ray structure of 16mer 7 reveals a compact, multiturn helix having a 9 Å inner pore.

Original languageEnglish (US)
Pages (from-to)6938-6942
Number of pages5
JournalOrganic Letters
Issue number17
StatePublished - Sep 4 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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