Perhaps more than almost any other subject of astrophysical study, the interstellar medium can be studied at any wavelength-from gamma rays to the radio-with each waveband providing unique and significant information. However, there are substantial limitations on the available data. One such limitation is the fact that very few lines of sight have been adequately observed in multiple wavebands. This in turn restricts our understanding of topics as fundamental as interstellar abundances and dust composition. I will review the reasons that such data limitations exist and specifically describe two accepted observing programs that will, in the near future, utilize a multiwavelength approach in studying interstellar dust. The first is a Chandra/HST program that will provide unique insight into dust composition by disentangling the gas-phase and dust-phase abundances of oxygen and iron. The second is a Spitzer/HST program that will examine the extinction curves of possible "translucent clouds" at wavelengths from the UV to the IR.