Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: A nationwide discovery cohort

Johanne M. Holst, Trine L. Plesner, Martin B. Pedersen, Henrik Frederiksen, Michael B. Møller, Michael R. Clausen, Marcus C. Hansen, Stephen Jacques Hamilton-Dutoit, Peter Nørgaard, Preben Johansen, Tobias Ramm Eberlein, Bo K. Mortensen, Gustav Mathiasen, Andreas Øvlisen, Rui Wang, Chao Wang, Weiwei Zhang, Hans Beier Ommen, Jesper Stentoft, Maja LudvigsenWayne Tam, Wing C. Chan, Giorgio Inghirami, Francesco d'Amore

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Myeloid and lymphoid malignancies are postulated to have distinct pathogenic mechanisms. The recent observation that patients with a myeloproliferative neoplasm have an increased risk of developing lymphoproliferative malignancies has challenged this assumption. We collected a nationwide cohort of patients with both malignancies. Patients diagnosed between 1990 and 2015 were identified through the national Danish Pathology Registry. We identified 599 patients with a myeloproliferative neoplasm and a concomitant or subsequent diagnosis of lymphoma. Histopathological review of the diagnostic samples from each patient led to a final cohort of 97 individuals with confirmed dual diagnoses of myeloproliferative neoplasm and lymphoma. The age range at diagnosis of these individuals was 19-94 years (median: 71 years). To avoid the inclusion of cases of therapy-induced myeloproliferative neoplasm occurring in patients previously treated for lymphoma, only patients with myeloproliferative neoplasm diagnosed unequivocally before the development of lymphoma were included. The average time interval between the diagnoses of the two malignancies was 1.5 years. In the majority of patients (90%) both diagnoses were established within 5 years of each other. Among the lymphoma entities, the frequency of peripheral T-cell lymphomas was markedly increased. Interestingly, all but one of the T-cell lymphomas were of angioimmunoblastic type. These findings suggest that a myeloproliferative neoplasm and lymphoproliferative malignancy developing in the same patient may have common pathogenic events, possibly already at the progenitor level. We believe that the molecular characterization of the newly developed biorepository will help to highlight the mechanisms driving the genesis and clonal evolution of these hematopoietic malignancies.

Original languageEnglish (US)
Pages (from-to)2432-2439
Number of pages8
JournalHaematologica
Volume105
Issue number10
DOIs
StatePublished - Oct 2020

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: A nationwide discovery cohort'. Together they form a unique fingerprint.

Cite this