Myocardial bridges are free from atherosclerosis: Overview of the underlying mechanisms

Yiannis S. Chatzizisis, George D. Giannoglou

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Myocardial bridging constitutes a congenital, usually benign, coronary abnormality defined as a segment of a major epicardial coronary artery that follows an intramural course through the myocardium. On the basis of clinical and histopathological data, myocardial bridges appear to be spared from atherosclerosis. Although the mechanisms involved are largely unknown, the surrounding myocardium appears to be a key factor by generating a unique atheroprotective hemodynamic microenvironment within bridges. The main components of this environment include low tensile stress and high shear stress. Reduced coronary wall motion due to external support of the surrounding myocardium may also play a role. Better investigation of these mechanisms in appropriate animal models is anticipated to advance our understanding of the pathophysiology of atherosclerosis, providing a framework for the development of new atheroprotective strategies.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalCanadian Journal of Cardiology
Volume25
Issue number4
DOIs
StatePublished - 2009

Keywords

  • Atherosclerosis
  • Coronary artery
  • Myocardial bridge
  • Shear stress
  • Tensile stress
  • Wall motion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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