TY - JOUR
T1 - Myocardial deformation assessed by longitudinal strain
T2 - Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects
AU - Shang, Quanliang
AU - Patel, Shivani
AU - Steinmetz, Michael
AU - Schuster, Andreas
AU - Danford, David A.
AU - Beerbaum, Philipp
AU - Sarikouch, Samir
AU - Kutty, Shelby
N1 - Funding Information:
Acknowledgements We thank Berthold Klas, BS, TomTec Imaging Systems, TomTec Corporation USA for technical assistance. SK receives support from the American Heart Association.
Funding Information:
Funding This study was part of the Magnetic Resonance Imaging Project of the Competence Network for Congenital Heart Defects funded by the German Federal Ministry of Education and Research (FKZ01G10210).
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.
AB - Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.
KW - Cardiac deformation
KW - Cardiovascular magnetic resonance
KW - Feature tracking
KW - Paediatric cardiology
KW - Strain
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U2 - 10.1007/s00330-017-5034-2
DO - 10.1007/s00330-017-5034-2
M3 - Article
C2 - 28875228
AN - SCOPUS:85029001144
VL - 28
SP - 1257
EP - 1266
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 3
ER -