Myocardial matrix metalloproteinase-2: Inside out and upside down

Ashley DeCoux, Merry L. Lindsey, Francisco Villarreal, Ricardo A. Garcia, Richard Schulz

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

Since their inaugural discovery in the early 1960s, matrix metalloproteinases (MMPs) have been shown to mediate multiple physiological and pathological processes. In addition to their canonical function in extracellular matrix (ECM) remodeling, research in the last decade has highlighted new MMP functions, including proteolysis of novel substrates beyond ECM proteins, MMP localization to subcellular organelles, and proteolysis of susceptible intracellular proteins in those subcellular compartments. This review will provide a comparison of the extracellular and intracellular roles of MMPs, illustrating that MMPs are far more interesting than the one-dimensional view originally taken. We focus on the roles of MMP-2 in cardiac injury and repair, as this is one of the most studied MMPs in the cardiovascular field. We will highlight how understanding all dimensions, such as localization of activity and timing of interventions, will increase the translational potential of research findings. Building upon old ideas and turning them inside out and upside down will help us to better understand how to move the MMP field forward.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume77
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Doxycycline
  • Heart failure
  • MMP-2
  • Myocardial ischemia and infarction
  • TIPTOP

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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