Myocardial Perfusion Imaging With Contrast Ultrasound

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


This report reviews the development and clinical application of myocardial perfusion imaging with myocardial contrast echocardiography (MCE). This includes the development of microbubble formulations that permit the detection of left ventricular contrast from venous injection and the imaging techniques that have been invented to detect the transit of these microbubbles through the microcirculation. The methods used to quantify myocardial perfusion during a continuous infusion of microbubbles are described. A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed.

Original languageEnglish (US)
Pages (from-to)176-187
Number of pages12
JournalJACC: Cardiovascular Imaging
Issue number2
StatePublished - Feb 2010


  • myocardial contrast echocardiography
  • ultrasound contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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