Myocardial protection in sepsis

Simon Shakar, Brian D. Lowes

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Sepsis with myocardial dysfunction is seen commonly. Beta-blockers have been used successfully to treat chronic heart failure based on the premise that chronically elevated adrenergic drive is detrimental to the myocardium. However, recent reports on the acute use of beta-blockers in situations with potential hemodynamic compromise have shown the risks associated with this approach. In critical situations, the main effect of adrenergic activation is to support cardiovascular function. Caution should be exercised in designing studies to assess beta-blockers in septic patients.

Original languageEnglish (US)
Article number177
JournalCritical Care
Issue number5
StatePublished - Sep 3 2008
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Myocardial protection in sepsis'. Together they form a unique fingerprint.

Cite this