Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

Yonggang Ma, Lisandra E. De Castro Brás, Hiroe Toba, Rugmani Padmanabhan Iyer, Michael E. Hall, Michael D. Winniford, Richard A. Lange, Suresh C. Tyagi, Merry L. Lindsey

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

The cardiac extracellular matrix (ECM) fills the space between cells, supports tissue organization, and transduces mechanical, chemical, and biological signals to regulate homeostasis of the left ventricle (LV). Following myocardial infarction (MI), a multitude of ECM proteins are synthesized to replace myocyte loss and form a reparative scar. Activated fibroblasts (myofibroblasts) are the primary source of ECM proteins, thus playing a key role in cardiac repair. A balanced turnover of ECM through regulation of synthesis by myofibroblasts and degradation by matrix metalloproteinases (MMPs) is critical for proper scar formation. In this review, we summarize the current literature on the roles of myofibroblasts, MMPs, and ECM proteins in MI-induced LV remodeling. In addition, we discuss future research directions that are needed to further elucidate the molecular mechanisms of ECM actions to optimize cardiac repair.

Original languageEnglish (US)
Pages (from-to)1113-1127
Number of pages15
JournalPflugers Archiv European Journal of Physiology
Volume466
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Extracellular matrix
  • MMP-9
  • Myocardial infarction
  • Myofibroblast
  • Proteomics
  • Review

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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    Ma, Y., De Castro Brás, L. E., Toba, H., Iyer, R. P., Hall, M. E., Winniford, M. D., Lange, R. A., Tyagi, S. C., & Lindsey, M. L. (2014). Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. Pflugers Archiv European Journal of Physiology, 466(6), 1113-1127. https://doi.org/10.1007/s00424-014-1463-9