Nano-enabled delivery of diverse payloads across complex biological barriers

Kathleen A. Ross; Timothy M. Brenza; Andrea M. Binnebose; Yashdeep Phanse; Anumantha G. Kanthasamy; Howard E. Gendelman; Aliasger K. Salem; Lyric C. Bartholomay; Bryan H. Bellaire; Balaji Narasimhan

doi:10.1016/j.jconrel.2015.08.039

Nano-enabled delivery of diverse payloads across complex biological barriers

Kathleen A. Ross, Timothy M. Brenza, Andrea M. Binnebose, Yashdeep Phanse, Anumantha G. Kanthasamy, Howard E. Gendelman, Aliasger K. Salem, Lyric C. Bartholomay, Bryan H. Bellaire, Balaji Narasimhan

Research output: Contribution to journal › Article

19 Scopus citations

Abstract

Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.

Original language	English (US)
Pages (from-to)	548-559
Number of pages	12
Journal	Journal of Controlled Release
Volume	219
DOIs	https://doi.org/10.1016/j.jconrel.2015.08.039
State	Published - Dec 10 2015

Keywords

Biological barriers
Blood-brain barrier
Drug delivery
Nanoparticle
Tumor microenvironment
Vector-borne disease

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2015.08.039

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Ross, K. A., Brenza, T. M., Binnebose, A. M., Phanse, Y., Kanthasamy, A. G., Gendelman, H. E., Salem, A. K., Bartholomay, L. C., Bellaire, B. H., & Narasimhan, B. (2015). Nano-enabled delivery of diverse payloads across complex biological barriers. Journal of Controlled Release, 219, 548-559. https://doi.org/10.1016/j.jconrel.2015.08.039

Nano-enabled delivery of diverse payloads across complex biological barriers. / Ross, Kathleen A.; Brenza, Timothy M.; Binnebose, Andrea M.; Phanse, Yashdeep; Kanthasamy, Anumantha G.; Gendelman, Howard E.; Salem, Aliasger K.; Bartholomay, Lyric C.; Bellaire, Bryan H.; Narasimhan, Balaji.

In: Journal of Controlled Release, Vol. 219, 10.12.2015, p. 548-559.

Research output: Contribution to journal › Article

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