Nano-enabled delivery of diverse payloads across complex biological barriers

Kathleen A. Ross, Timothy M. Brenza, Andrea M. Binnebose, Yashdeep Phanse, Anumantha G. Kanthasamy, Howard E. Gendelman, Aliasger K. Salem, Lyric C. Bartholomay, Bryan H. Bellaire, Balaji Narasimhan

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.

Original languageEnglish (US)
Pages (from-to)548-559
Number of pages12
JournalJournal of Controlled Release
StatePublished - Dec 10 2015


  • Biological barriers
  • Blood-brain barrier
  • Drug delivery
  • Nanoparticle
  • Tumor microenvironment
  • Vector-borne disease

ASJC Scopus subject areas

  • Pharmaceutical Science


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