TY - JOUR
T1 - Nano-enabled delivery of diverse payloads across complex biological barriers
AU - Ross, Kathleen A.
AU - Brenza, Timothy M.
AU - Binnebose, Andrea M.
AU - Phanse, Yashdeep
AU - Kanthasamy, Anumantha G.
AU - Gendelman, Howard E.
AU - Salem, Aliasger K.
AU - Bartholomay, Lyric C.
AU - Bellaire, Bryan H.
AU - Narasimhan, Balaji
PY - 2015/12/10
Y1 - 2015/12/10
N2 - Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
AB - Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
KW - Biological barriers
KW - Blood-brain barrier
KW - Drug delivery
KW - Nanoparticle
KW - Tumor microenvironment
KW - Vector-borne disease
UR - http://www.scopus.com/inward/record.url?scp=84947496131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947496131&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2015.08.039
DO - 10.1016/j.jconrel.2015.08.039
M3 - Article
C2 - 26315817
AN - SCOPUS:84947496131
VL - 219
SP - 548
EP - 559
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -