TY - JOUR
T1 - Nano-enabled delivery of diverse payloads across complex biological barriers
AU - Ross, Kathleen A.
AU - Brenza, Timothy M.
AU - Binnebose, Andrea M.
AU - Phanse, Yashdeep
AU - Kanthasamy, Anumantha G.
AU - Gendelman, Howard E.
AU - Salem, Aliasger K.
AU - Bartholomay, Lyric C.
AU - Bellaire, Bryan H.
AU - Narasimhan, Balaji
N1 - Funding Information:
B.N. gratefully acknowledges the support from the U.S. Army Medical Center and Materiel Command W81-XWH-11-10700 ), the Bill and Melinda Gates Foundation Grand Challenges Exploration OPP 1087610 ), the Iowa State Nanovaccine Initiative , and the Vlasta Klima Balloun Professorship. A.G.K. also acknowledges the support from the U.S. Army Medical Center and Materiel Command W81-XWH-11-10700 ), the National Institutes of Health ( NS 074443 ), and the W. Eugene and Linda Lloyd Endowed Chair. H.E.G. acknowledges the support from the National Institutes of Health ( 5R01 AG043540-02 , P01 DA028555 , R01 NS36126 , 2R01 NS034239 , P30 MH062261 ). A.K.S. gratefully acknowledges the support from the National Cancer Institute at the National Institutes of Health ( P50 CA97274 /UI Mayo Clinic Lymphoma SPORE Grant and P30 CA086862 Cancer Center Support Grant) and the Lyle and Sharon Bighley Professorship. L.C.B. gratefully acknowledges support from the Foundation for the National Institutes of Health through the Vector-based Transmission of Control: Discover Research program of the Grand Challenges in Global Health initiative and the Iowa State Nanovaccine Initiative . B.H.B. is also grateful of the support from the Bill and Melinda Gates Foundation Grand Challenges Exploration ( OPP 1087610 ) and the Iowa State Nanovaccine Initiative .
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/12/10
Y1 - 2015/12/10
N2 - Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
AB - Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
KW - Biological barriers
KW - Blood-brain barrier
KW - Drug delivery
KW - Nanoparticle
KW - Tumor microenvironment
KW - Vector-borne disease
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UR - http://www.scopus.com/inward/citedby.url?scp=84947496131&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2015.08.039
DO - 10.1016/j.jconrel.2015.08.039
M3 - Article
C2 - 26315817
AN - SCOPUS:84947496131
VL - 219
SP - 548
EP - 559
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -