Nanocarriers for delivery of platinum anticancer drugs

Hardeep S. Oberoi, Natalia V. Nukolova, Alexander V. Kabanov, Tatiana K. Bronich

Research output: Contribution to journalReview article

222 Scopus citations

Abstract

Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

Original languageEnglish (US)
Pages (from-to)1667-1685
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number13-14
DOIs
StatePublished - 2013

Keywords

  • Block ionomer complex
  • Dendrime
  • Drug delivery systems
  • Liposome
  • Micelle
  • Nanoparticle
  • Nanotube
  • Platinum drugs
  • Polymer conjugate

ASJC Scopus subject areas

  • Pharmaceutical Science

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