Nanocomposite hydrogels for tissue engineering applications

Azadeh Mostafavi, Jacob Quint, Carina Russell, Ali Tamayol

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Tissue engineering is an emerging research area that serves as a tool for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or damaged organs. From a materials perspective, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Of all the possible scaffolding biomaterials, hydrogels have emerged as a promising candidate for their ability to mimic extracellular matrix of soft tissues. The majority of hydrogels, however, do not provide the physicochemical and biological characteristics and properties required for optimal cell growth and tissue function. In this chapter, we discuss the challenges associated with various types of hydrogels and will highlight the benefits of nanocomposites made of various nanoparticles and hydrogels for tissue engineering applications. In addition, emerging technologies and the opportunities for engineering more effective hydrogel-based scaffolds are briefly discussed.

Original languageEnglish (US)
Title of host publicationBiomaterials for Organ and Tissue Regeneration
Subtitle of host publicationNew Technologies and Future Prospects
PublisherElsevier
Pages499-528
Number of pages30
ISBN (Electronic)9780081029060
ISBN (Print)9780081029077
DOIs
StatePublished - Jan 1 2020

Keywords

  • Nanocomposite hydrogel systems
  • functionalization
  • nanomaterials
  • tissue engineering

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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