Nanocomposite scaffolds for bone tissue engineering: Design, fabrication, surface modification and sustained release of growth factor

Min Wang, Bin Duan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

From the material point of view, the extracellular matrix (ECM) of bone is a natural nanocomposite consisting of an organic matrix (mainly collagen) and inorganic nanofillers (bone apatite) which are inserted in a parallel way into the collagen fibrils. For human bone tissue repair or regeneration, nanocomposites consisting of a biodegradable polymer matrix and nano-sized fillers such as bioactive ceramics or glasses, which mimic the hierarchical structure of bone, are considered a promising strategy. Combining living cells with biodegradable materials and/or bioactive component(s), the concept of tissue engineering first elucidated in the early 1990s represented a paradigm shift from tissue grafting, with autografts being the gold standard, or even completely from prosthesis implantation. In scaffold-based tissue engineering, scaffolds play an important role for tissue regeneration. Currently, acellular scaffolds with or without biomolecules such as growth factors are considered as an effective strategy for certain tissue repair due to their relatively low costs and easier process to gain surgeons' acceptance and regulator)' approval. In the current study, integrating an advanced manufacturing technique, nanocomposite material and controlled delivery of growth factor to form multifunctional tissue engineering scaffolds was investigated. Three-dimensional, osteoconductive and totally biodegradable calcium phosphate (Ca-P)/poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) nanocomposite scaffolds with customized architecture, controlled porosity and interconnecting pores were designed and fabricated using selective laser sintering (SLS). The surface of nanocomposite scaffolds was modified with gelatin and then heparin, which facilitated the incorporation of a growth factor, recombinant human bone morphogenetic protein-2 (rhBMP-2). Experimental results demonstrated the effectiveness of this strategy in guiding the osteogenic differentiation of mesenchymal stem cells. Together with osteoconductive nanocomposite material and controlled growth factor delivery, the use of SLS technique to form complex scaffolds provides a promising route towards individualized bone tissue regeneration.

Original languageEnglish (US)
Title of host publicationSoft Matter, Biological Materials and Biomedical Materials - Synthesis, Characterization and Applications
Pages99-110
Number of pages12
DOIs
StatePublished - 2011
Event2010 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 29 2010Dec 3 2010

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1301
ISSN (Print)0272-9172

Conference

Conference2010 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/29/1012/3/10

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Nanocomposite scaffolds for bone tissue engineering: Design, fabrication, surface modification and sustained release of growth factor'. Together they form a unique fingerprint.

  • Cite this

    Wang, M., & Duan, B. (2011). Nanocomposite scaffolds for bone tissue engineering: Design, fabrication, surface modification and sustained release of growth factor. In Soft Matter, Biological Materials and Biomedical Materials - Synthesis, Characterization and Applications (pp. 99-110). (Materials Research Society Symposium Proceedings; Vol. 1301). https://doi.org/10.1557/opl.2011.470