Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer

Ling Ding, Siyuan Tang, Ao Yu, Anlin Wang, Weimin Tang, Huizhen Jia, David Oupický

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic cancer (PC) is a fatal human cancer, whose progression is highly dependent on the nervous tumor microenvironment. In the present study, cationic perfluorocarbon nanoemulsions were employed as an intraperitoneal delivery platform to facilitate the delivery and penetration of a therapeutic small interfering RNA (siRNA) to orthotopic pancreatic tumors. The nanoemulsion was used to silence the expression of the nerve growth factor (NGF) as a way of favorably modulating the tumor-neuronal interactions in pancreatic tumors. The nanoemulsions exhibited deep tumor penetration that was dependent on exocytosis and enhanced NGF gene silencing in vitro and in vivo when compared with control polycation/siRNA polyplexes, leading to the effective and safe suppression of tumor growth in orthotopic PC. Overall, emulsion-assisted delivery of NGF siRNA is a promising treatment approach for PC by targeting the interactions between the tumor cells and the nervous microenvironment.

Original languageEnglish (US)
Pages (from-to)10015-10029
Number of pages15
JournalACS Applied Materials and Interfaces
Volume14
Issue number8
DOIs
StatePublished - Mar 2 2022

Keywords

  • CXCR4
  • intraperitoneal delivery
  • nanoemulsion
  • nerve growth factor
  • pancreatic cancer

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint

Dive into the research topics of 'Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer'. Together they form a unique fingerprint.

Cite this