Nanofibrous scaffolds with biomimetic structure

Shahla Khalili, Saied Nouri Khorasani, Mohammad Razavi, Batol Hashemi Beni, Fariba Heydari, Ali Tamayol

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

This research studies the effect of using a grid-like pattern as a collector on increasing the pore size of the electrospun gelatin/cellulose acetate/elastin scaffolds. The morphological study showed an enlargement in pore size and a decline in fiber diameter in comparison with the scaffold fabricated using conventional flat sheet collectors. The use of the pattern increased the swelling ratio and degradation rate of the scaffold. Investigating the tensile properties of scaffolds revealed that the patterned collector increased the elongation at break up to 145%. In vitro experiments revealed the patterned scaffold as a good substrate for attachment and proliferation of fibroblast cells. Overall, our results indicated that the patterned scaffold of gelatin/cellulose acetate/elastin could provide a better microenvironment for fibroblast cells compared to the conventional scaffolds.

Original languageEnglish (US)
Pages (from-to)370-376
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume106
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • cellulose acetate
  • elastin
  • gelatin
  • pore size
  • scaffolds
  • skin tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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  • Cite this

    Khalili, S., Nouri Khorasani, S., Razavi, M., Hashemi Beni, B., Heydari, F., & Tamayol, A. (2018). Nanofibrous scaffolds with biomimetic structure. Journal of Biomedical Materials Research - Part A, 106(2), 370-376. https://doi.org/10.1002/jbm.a.36246