Nanofibrous silver-coated polymeric scaffolds with tunable electrical properties

Adnan Memic, Musab Aldhahri, Ali Tamayol, Pooria Mostafalu, Mohamed Shaaban Abdel-Wahab, Mohamadmahdi Samandari, Kamyar Mollazadeh Moghaddam, Nasim Annabi, Sidi A. Bencherif, Ali Khademhosseini

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications.

Original languageEnglish (US)
Article number63
JournalNanomaterials
Volume7
Issue number3
DOIs
StatePublished - Mar 13 2017

Keywords

  • Electrical properties
  • Electrospinning
  • Flexible electronics
  • Nanocoatings

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

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  • Cite this

    Memic, A., Aldhahri, M., Tamayol, A., Mostafalu, P., Abdel-Wahab, M. S., Samandari, M., Moghaddam, K. M., Annabi, N., Bencherif, S. A., & Khademhosseini, A. (2017). Nanofibrous silver-coated polymeric scaffolds with tunable electrical properties. Nanomaterials, 7(3), [63]. https://doi.org/10.3390/nano7030063