Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

Lingdong Quan, Yijia Zhang, Bart J. Crielaard, Anand Dusad, Subodh M. Lele, Cristianne J.F. Rijcken, Josbert M. Metselaar, Hana Kostková, Tomáš Etrych, Karel Ulbrich, Fabian Kiessling, Ted R. Mikuls, Wim E. Hennink, Gert Storm, Twan Lammers, Dong Wang

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

As an emerging research direction, nanomedicine has been increasingly utilized to treat inflammatory diseases. In this head-to-head comparison study, four established nanomedicine formulations of dexamethasone, including liposomes (L-Dex), core-cross-linked micelles (M-Dex), slow releasing polymeric prodrugs (P-Dex-slow), and fast releasing polymeric prodrugs (P-Dex-fast), were evaluated in an adjuvant-induced arthritis rat model with an equivalent dose treatment design. It was found that after a single i.v. injection, the formulations with the slower drug release kinetics (i.e., M-Dex and P-Dex-slow) maintained longer duration of therapeutic activity than those with relatively faster drug release kinetics, resulting in better joint protection. This finding will be instructional in the future development and optimization of nanomedicines for the clinical management of rheumatoid arthritis. The outcome of this study also illustrates the value of such head-to-head comparison studies in translational nanomedicine research.

Original languageEnglish (US)
Pages (from-to)458-466
Number of pages9
JournalACS Nano
Volume8
Issue number1
DOIs
StatePublished - Jan 28 2014

Keywords

  • HPMA copolymer
  • dexamethasone
  • drug targeting
  • glucocorticoid
  • inflammation
  • liposome
  • micelle
  • nanomedicine
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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    Quan, L., Zhang, Y., Crielaard, B. J., Dusad, A., Lele, S. M., Rijcken, C. J. F., Metselaar, J. M., Kostková, H., Etrych, T., Ulbrich, K., Kiessling, F., Mikuls, T. R., Hennink, W. E., Storm, G., Lammers, T., & Wang, D. (2014). Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes. ACS Nano, 8(1), 458-466. https://doi.org/10.1021/nn4048205