TY - JOUR
T1 - Nanoparticles for cancer gene therapy
T2 - Recent advances, challenges, and strategies
AU - Wang, Kui
AU - Kievit, Forrest M.
AU - Zhang, Miqin
N1 - Funding Information:
We acknowledge financial support from NIH grants R01CA161953 and R01CA172455 to M.Z. K.W. acknowledges support from the College of Engineering Dean’s Fellowship (the Scott Fellowship and the Marsh Fellowship) at University of Washington. We also acknowledge Prof. John R. Silber’s thoughtful comments on the revision of the manuscript.
Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.
AB - Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.
KW - Cancer gene therapy
KW - Gene delivery
KW - Nanoparticles
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U2 - 10.1016/j.phrs.2016.10.016
DO - 10.1016/j.phrs.2016.10.016
M3 - Article
C2 - 27771464
AN - SCOPUS:84992337449
VL - 114
SP - 56
EP - 66
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -