Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies

Kui Wang, Forrest M. Kievit, Miqin Zhang

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalPharmacological Research
StatePublished - Dec 1 2016
Externally publishedYes


  • Cancer gene therapy
  • Gene delivery
  • Nanoparticles

ASJC Scopus subject areas

  • Pharmacology


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