Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

Amir Nasajpour, Serena Mandla, Sindu Shree, Ebrahim Mostafavi, Roholah Sharifi, Akbar Khalilpour, Saghi Saghazadeh, Shabir Hassan, Michael J. Mitchell, Jeroen Leijten, Xu Hou, Alireza Moshaverinia, Nasim Annabi, Rainer Adelung, Yogendra Kumar Mishra, Su Ryon Shin, Ali Tamayol, Ali Khademhosseini

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

Original languageEnglish (US)
Pages (from-to)6235-6240
Number of pages6
JournalNano Letters
Volume17
Issue number10
DOIs
StatePublished - Oct 11 2017

Keywords

  • Branched tetrapod nanoparticles
  • antimicrobial
  • electrospinning
  • nanocomposites
  • scaffolds
  • zinc oxide

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Nasajpour, A., Mandla, S., Shree, S., Mostafavi, E., Sharifi, R., Khalilpour, A., Saghazadeh, S., Hassan, S., Mitchell, M. J., Leijten, J., Hou, X., Moshaverinia, A., Annabi, N., Adelung, R., Mishra, Y. K., Shin, S. R., Tamayol, A., & Khademhosseini, A. (2017). Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Letters, 17(10), 6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929