National survey of neonatal transfusion practices: I. Red blood cell therapy

G. J. Levy, R. G. Strauss, H. Hume, L. Schloz, M. A. Albanese, J. Blazina, A. Werner, C. Sotelo-Avila, C. Barrasso, V. Blanchette, P. I. Warkentin, S. Pepkowitz, A. M. Mauer, D. Hines

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Neonatal blood component transfusion practices during 1989 were surveyed via a questionnaire developed by the Pediatric Hemotherapy Committee of the American Association of Blood Banks. Of 1790 questionnaires mailed, 452 were selected to form the database for this analysis because they were from institutions in which neonates were transfused. Nearly all institutions contained intensive care units directed by neonatologists and were involved in the management of high-risk infants. Results from institutions serving as the primary pediatric teaching hospital of a medical school were compared with those with no medical school affiliation. Thirty-six percent of primary pediatric teaching hospitals and 52% of hospitals with no medical school affiliation performed pretransfusion testing in excess of that required, resulting in additional blood loss in neonates. Sixty-six percent of primary pediatric teaching hospitals used fresh frozen plasma to adjust the hematocrit of red blood cell concentrates prior to transfusion (a practice increasing donor exposure), compared with only 29% of hospitals with no medical school affiliation. The usual indication for small-volume red blood cell transfusions in severely ill neonates was to maintain a desired hematocrit level, whereas for stable infants, red blood cell transfusions were given to treat symptomatic anemia, rather than to maintain a predetermined hematocrit. As found in 1985, neonatal transfusion practices in 1989 were variable. However, improvements have occurred since 1985 to suggest that further research and educational efforts may serve to promote even better neonatal transfusion therapy.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
Issue number3
StatePublished - 1993


  • additive solutions
  • compatibility testing
  • directed donors
  • neonatal transfusions
  • red blood cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'National survey of neonatal transfusion practices: I. Red blood cell therapy'. Together they form a unique fingerprint.

Cite this