Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies

Shannon D. Manning; Stephen Wood; Katherine Kasha; Denis Martin; Stéphane Rioux; Bernard Brodeur; H. Dele Davies

doi:10.1016/j.vaccine.2006.06.020

Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies

Shannon D. Manning, Stephen Wood, Katherine Kasha, Denis Martin, Stéphane Rioux, Bernard Brodeur, H. Dele Davies

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Sip is a surface-exposed protein of GBS, which causes severe neonatal disease. Because Sip elicits a protective immune response in mice, we assessed whether pregnant women and newborns have Sip antibodies. Sera were collected from 644 pregnant women and 176 of their healthy newborns, and 10 newborns with GBS disease and their mothers. Using ELISA, most (99%) women and newborns (97%) had serum Sip antibodies, as did most newborns followed through 6 months. This suggests that naturally occurring Sip antibodies cross the placenta and persist into infancy, which underscores the need to study Sip further as a potential vaccine candidate.

Original language	English (US)
Pages (from-to)	6905-6912
Number of pages	8
Journal	Vaccine
Volume	24
Issue number	47-48
DOIs	https://doi.org/10.1016/j.vaccine.2006.06.020
State	Published - Nov 17 2006
Externally published	Yes

Keywords

Antibodies
Group B Streptococcus
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2006.06.020

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title = "Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies",

abstract = "Sip is a surface-exposed protein of GBS, which causes severe neonatal disease. Because Sip elicits a protective immune response in mice, we assessed whether pregnant women and newborns have Sip antibodies. Sera were collected from 644 pregnant women and 176 of their healthy newborns, and 10 newborns with GBS disease and their mothers. Using ELISA, most (99%) women and newborns (97%) had serum Sip antibodies, as did most newborns followed through 6 months. This suggests that naturally occurring Sip antibodies cross the placenta and persist into infancy, which underscores the need to study Sip further as a potential vaccine candidate.",

keywords = "Antibodies, Group B Streptococcus, Vaccine",

author = "Manning, {Shannon D.} and Stephen Wood and Katherine Kasha and Denis Martin and St{\'e}phane Rioux and Bernard Brodeur and Davies, {H. Dele}",

note = "Funding Information: This work was supported by the Alberta Heritage Foundation for Medical Research and Alberta Children's Hospital Foundation (H.D.D.), Public Health Service grant AI066081 from the National Institutes of Health and in part by ID Biomedical (D.M.). ",

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AU - Wood, Stephen

AU - Kasha, Katherine

AU - Martin, Denis

AU - Rioux, Stéphane

AU - Brodeur, Bernard

AU - Davies, H. Dele

N1 - Funding Information: This work was supported by the Alberta Heritage Foundation for Medical Research and Alberta Children's Hospital Foundation (H.D.D.), Public Health Service grant AI066081 from the National Institutes of Health and in part by ID Biomedical (D.M.).

PY - 2006/11/17

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AB - Sip is a surface-exposed protein of GBS, which causes severe neonatal disease. Because Sip elicits a protective immune response in mice, we assessed whether pregnant women and newborns have Sip antibodies. Sera were collected from 644 pregnant women and 176 of their healthy newborns, and 10 newborns with GBS disease and their mothers. Using ELISA, most (99%) women and newborns (97%) had serum Sip antibodies, as did most newborns followed through 6 months. This suggests that naturally occurring Sip antibodies cross the placenta and persist into infancy, which underscores the need to study Sip further as a potential vaccine candidate.

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Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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