Near-Full-Length Genetic Characterization of a Novel HIV-1 Unique Recombinant with Similarities to A1, CRF01-AE, and CRFO2-AG Viruses in Yaoundé, Cameroon

Arpan Acharya, Julius Y. Fonsah, Dora Mbanya, Alfred K. Njamnshi, Georgette D. Kanmogne

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Variations in the HIV genome influence HIV/AIDS epidemiology. We report here a novel HIV-1 unique recombinant form (URF) isolated from an HIV-infected female (NACMR092) in Cameroon, based on the analyses of near-full-length viral genome (partial gag, full-length pol, env, tat, rev, vif, vpr, vpu, and nef genes, and partial 3′-long terminal repeat). Phylogeny, recombination breakpoints, and recombination map analyses showed that NACMR092 was infected with a mosaic URF that had eight breakpoints (two in gag, one in pol, one in vpr, two in env, and two in the nef regions), nine subgenomic regions, and included fragments that had important similarities with HIV-1 subtypes A1, CRF02-AG, and CRF01-AE. This novel mosaic URF underscores complex recombination events occurring between HIV-1 subtypes circulating in Cameroon. Continued monitoring and detection of such recombinants and accurate classification of HIV genotype is important for tracking viral molecular epidemiology and antigenic diversity.

Original languageEnglish (US)
Pages (from-to)762-768
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume35
Issue number8
DOIs
StatePublished - Aug 2019

Keywords

  • Cameroon
  • HIV-1
  • NACMR092
  • near-full-length genome sequence
  • phylogenetic trees
  • recombination breakpoints

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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