Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death

Derron A. Alves, Anna N. Honko, Mark G. Kortepeter, Mei Sun, Joshua C. Johnson, Luis A. Lugo-Roman, Lisa E. Hensley

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalJournal of Infectious Diseases
Volume213
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Ebola virus disease; Ebola virus; sequelae; macaque; rhesus; intramuscular; delayed death; eye; brain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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