Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death

Derron A. Alves; Anna N. Honko; Mark G. Kortepeter; Mei Sun; Joshua C. Johnson; Luis A. Lugo-Roman; Lisa E. Hensley

doi:10.1093/infdis/jiv357

Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death

Derron A. Alves, Anna N. Honko, Mark G. Kortepeter, Mei Sun, Joshua C. Johnson, Luis A. Lugo-Roman, Lisa E. Hensley

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease.

Original language	English (US)
Pages (from-to)	57-60
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	213
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiv357
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Ebola virus disease; Ebola virus; sequelae; macaque; rhesus; intramuscular; delayed death; eye; brain

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiv357

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Alves, D. A., Honko, A. N., Kortepeter, M. G., Sun, M., Johnson, J. C., Lugo-Roman, L. A., & Hensley, L. E. (2016). Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death. Journal of Infectious Diseases, 213(1), 57-60. https://doi.org/10.1093/infdis/jiv357

Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death. / Alves, Derron A.; Honko, Anna N.; Kortepeter, Mark G. et al.
In: Journal of Infectious Diseases, Vol. 213, No. 1, 01.01.2016, p. 57-60.

Research output: Contribution to journal › Article › peer-review

Alves, DA, Honko, AN, Kortepeter, MG, Sun, M, Johnson, JC, Lugo-Roman, LA & Hensley, LE 2016, 'Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death', Journal of Infectious Diseases, vol. 213, no. 1, pp. 57-60. https://doi.org/10.1093/infdis/jiv357

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abstract = "A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease.",

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Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola virus-infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death

Abstract

Keywords

ASJC Scopus subject areas

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