Needle-core biopsy in the pathologic diagnosis of malignant lymphoma showing high reproducibility among pathologists

Qinglong Hu, Hina Naushad, Qingmei Xie, Islam Al-Howaidi, Minghua Wang, Kai Fu

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objectives: To evaluate the role of needle-core biopsy in the pathologic diagnosis of lymphoma. Methods: One hundred and five cases with clinical suspicion for lymphoma were studied by 3 hematopathologists mimicking daily diagnostic service. The diagnostic result sheets were analyzed for diagnostic accuracy and reproducibility. The histologic pattern recognition by the 3 hematopathologists was also analyzed. Results: The overall diagnostic accuracy, based on the consensus diagnosis, was 85% to 87%. High reproducibility of diagnosis in lymphoma was observed among pathologists. The tissue size was associated with the percentage of definitive diagnosis. Histologic patterns were well recognized on core tissues. Conclusions: Needle-core biopsy is an effective technique for the diagnosis of lymphoma and should be considered the first-line procedure for cases with suspicion for lymphoma.

Original languageEnglish (US)
Pages (from-to)238-247
Number of pages10
JournalAmerican journal of clinical pathology
Volume140
Issue number2
DOIs
StatePublished - Aug 1 2013

Keywords

  • Lymphoma
  • Needle-core biopsy
  • Pathologic diagnosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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