Neither dorsal root nor baroreceptor afferents are necessary for eliciting the renal responses to acute intravascular volume expansion in the primate Macaca fascicularis

J. P. Gilmore, T. V. Peterson, I. H. Zucker

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The authors determined the contribution of the dorsal roots, vagi, and sino-aortic nerves to the renal responses to acute isotonic, isooncotic intravascular volume expansion in the nonhuman primate, Macaca fascicularis. Expansion of the estimated blood volume by 15% produced a significant natriuresis and diuresis. There was no significant difference between the time to peak response for either. Neither dorsal rhizotomy (C6-T7) nor vagotomy and sino-aortic denervation had a significant effect on these responses. The authors conclude that these pathways are not necessary for eliciting the renal responses to hypervolemia in the nonhuman primate.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalCirculation Research
Volume45
Issue number1
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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