Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma

H. R. Alexander, J. L. Grem, H. I. Pass, M. Hamilton, N. McAtee, D. L. Fraker, C. J. Allegra

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Gastric adenocarcinoma is typically diagnosed at an advanced stage, and even with 'curative' gastrectomy, most patients die of recurrent disease. Neoadjuvant chemotherapy for locally advanced gastric cancer is an experimental treatment strategy that may increase resectability and improve survival for patients afflicted with an almost uniformly fatal neoplasm. At our institution, we are evaluating the efficacy of fluorouracil, leucovorin, and interferon alfa-2A administered for three cycles, followed by surgery and consolidation therapy for patients with T3-4, N1-2, M0 gastric adenocarcinoma. The rationale for the use of neoadjuvant therapy combined with radical extirpative surgery in this setting and related issues are discussed.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
Issue number5
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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