Neonatal group B streptococcus disease in developing countries: Are we ready to deploy a vaccine?

Pui Ying Iroh Tam, Shirley F. Delair, Stephen K. Obaro

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Group B streptococcus (GBS) disease is the leading cause of neonatal sepsis in developed countries and has high case fatality rates. In developing countries, however, the burden of GBS is less clear; this is due to a lack of studies using optimal diagnostic, clinical and laboratory techniques and is complicated by the wide availability of non-prescription antibiotics to the general population and in peripartum patients. There is an urgent need for prospective, population-based surveillance to provide an accurate assessment of neonatal GBS disease burden in developing countries, which remains largely unrecognized, and consequently obscures the potential relevance of GBS vaccination in these populations. Preliminary data on GBS vaccines are promising as a preventive tool for neonatal GBS infection, more so than any other currently available public health initiative.

Original languageEnglish (US)
Pages (from-to)1401-1403
Number of pages3
JournalExpert Review of Vaccines
Issue number11
StatePublished - Nov 2 2015


  • Streptococcus agalactiae
  • broad-spectrum antimicrobial use
  • developing countries
  • group B streptococcus
  • intrapartum antibiotic prophylaxis
  • neonatal sepsis
  • vaccination

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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