Neonatal herpes simplex virus infections

Swetha G. Pinninti, David W. Kimberlin

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Neonatal herpes simplex virus (HSV) is an uncommon but devastating infection in the newborn, associated with significant morbidity and mortality. The use of PCR for identification of infected infants and acyclovir for treatment has significantly improved the prognosis for affected infants. The subsequent use of suppressive therapy with oral acyclovir following completion of parenteral treatment of acute disease has further enhanced the long-term prognosis for these infants. This review article will discuss the epidemiology, risk factors and routes of acquisition, clinical presentation, and evaluation of an infant suspected to have the infection, and treatment of proven neonatal HSV disease.

Original languageEnglish (US)
Pages (from-to)168-175
Number of pages8
JournalSeminars in Perinatology
Volume42
Issue number3
DOIs
StatePublished - Apr 2018

Keywords

  • Acyclovir
  • HSV
  • Neonatal
  • PCR

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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