neu Is not involved in N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder carcinoma or 2-amino-4-(5-nitro-2-furyl)thiazole transformation of rat bladder epithelial cells

Angela M. Mann, Makoto Asamoto, Tsuneo Masui, Timothy Macatee, Steven H. Eklund, Samuel M. Cohen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Enhanced c-erbB-2/neu expression has been linked with a poor prognosis in human bladder cancer. Previous reports have shown that a point mutation at nucleotide T2012 in the coding region of the transmembrane domain of the rat gene is sufficient to confer transformation potential on this gene. We examined the comparative levels of p185neu as well as the sequence around the hotspot (T2012) of the neu gene of rat bladder cells transformed by 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) or established in culture from N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT)-induced rat bladder tumors. We concluded that increased p185neu expression did not correlate significantly with tumorigenicity. No alterations in nucleotide sequences of the neu gene were observed in either in vitro model.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalCancer Letters
Volume84
Issue number2
DOIs
StatePublished - Sep 15 1994

Keywords

  • Chemical transformation
  • Rat bladder cells
  • neu gene
  • p185 expression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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