Neural control of the circulation in heart failure and coronary ischaemia: Introduction

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

1. A large gap in our knowledge of the reflex control of the circulation still exits in the setting of chronic heart failure. This symposium will provide state-of-the-art experimental data on the reflex regulation of the circulation in heart failure and myocardial ischaemia. 2. Alterations in arterial baroreflex and cardiopulmonary reflexes contribute to the increase in sympathetic tone in this disease state. Additionally, changes in neurohormones, such as angiotensin, are thought to contribute. 3. Coronary ischaemia is associated with activation of both vagal and sympathetic reflexes of cardiac origin. The balance between activation of these two reflexes will determine the ultimate change in sympathetic outflow. 4. Sensory endings in the myocardium are exquisitely sensitive to local mediators, such as prostaglandins, oxygen-derived free radicals, adenosine and bradykinin.

Original languageEnglish (US)
Pages (from-to)685-687
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume23
Issue number8
DOIs
StatePublished - Jan 1 1996

Keywords

  • Cardiovascular reflexes
  • Heart failure
  • Noradrenaline
  • Sympathetic nerves

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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