Neural regulation in experimental heart failure

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The hallmarks of the chronic heart failure state are alterations in autonomic reflexes, neurohumoral drive and fluid balance. The available evidence suggests that several factors contribute to these alterations. These may include peripheral as well as central nervous system abnormalities. However, recent evidence from animals with experimental heart failure suggests that alterations in central neural sites involved in regulating sympathetic outflow may be important in the alterations in autonomic reflexes, neurohumoral drive and fluid balance commonly observed in heart failure. Many of these central mechanisms have not been extensively studied; a comprehensive understanding of these mechanisms will enhance our ability to treat the heart failure condition and its cardiovascular complications.

Original languageEnglish (US)
Pages (from-to)283-294
Number of pages12
JournalBailliere's Clinical Neurology
Issue number2
StatePublished - 1997


  • Autonomic reflexes
  • Central mechanisms
  • Heart failure
  • NO
  • PVN

ASJC Scopus subject areas

  • Clinical Neurology


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