Neural regulations of the tumor microenvironment

Anthony C. Restaino, Paola D. Vermeer

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The identification of nerves in the tumor microenvironment has ushered in a new area of research in cancer biology. Numerous studies demonstrate the presence of various types of peripheral nerves (sympathetic, parasympathetic, sensory) within the tumor microenvironment; moreover, an increased density of nerves in the tumor microenvironment correlates with worse prognosis. In this review, we address the current understanding of nerve-mediated alterations of the tumor microenvironment and how they impact disease through a variety of processes, including direct nerve-cancer cell communication, alteration of the infiltrative immune population, and alteration of stromal components.

Original languageEnglish (US)
Pages (from-to)29-42
Number of pages14
JournalFASEB BioAdvances
Issue number1
StatePublished - Jan 2022
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Cancer Research
  • Molecular Medicine
  • Physiology


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