TY - JOUR
T1 - Neural regulations of the tumor microenvironment
AU - Restaino, Anthony C.
AU - Vermeer, Paola D.
N1 - Funding Information:
We gratefully acknowledge David C. Restaino for assisting with editing of the manuscript. We are also grateful to Jeffrey Barr, Austin Walz, Allison Kruse, Caitlin Williamson, Craig Welbon, Payal Ghosh, William C. Spanos, and Steven Powell for critical discussion of topics included in the article.
Publisher Copyright:
© 2021 The Authors FASEB BioAdvances published by The Federation of American Societies for Experimental Biology
PY - 2022/1
Y1 - 2022/1
N2 - The identification of nerves in the tumor microenvironment has ushered in a new area of research in cancer biology. Numerous studies demonstrate the presence of various types of peripheral nerves (sympathetic, parasympathetic, sensory) within the tumor microenvironment; moreover, an increased density of nerves in the tumor microenvironment correlates with worse prognosis. In this review, we address the current understanding of nerve-mediated alterations of the tumor microenvironment and how they impact disease through a variety of processes, including direct nerve-cancer cell communication, alteration of the infiltrative immune population, and alteration of stromal components.
AB - The identification of nerves in the tumor microenvironment has ushered in a new area of research in cancer biology. Numerous studies demonstrate the presence of various types of peripheral nerves (sympathetic, parasympathetic, sensory) within the tumor microenvironment; moreover, an increased density of nerves in the tumor microenvironment correlates with worse prognosis. In this review, we address the current understanding of nerve-mediated alterations of the tumor microenvironment and how they impact disease through a variety of processes, including direct nerve-cancer cell communication, alteration of the infiltrative immune population, and alteration of stromal components.
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U2 - 10.1096/fba.2021-00066
DO - 10.1096/fba.2021-00066
M3 - Review article
C2 - 35024571
AN - SCOPUS:85114684600
SN - 2573-9832
VL - 4
SP - 29
EP - 42
JO - FASEB BioAdvances
JF - FASEB BioAdvances
IS - 1
ER -