Neural response to self- and other referential praise and criticism in generalized social phobia

Karina Blair, Marilla Geraci, Jeffrey Devido, Daniel McCaffrey, Gang Chen, Meena Vythilingam, Pamela Ng, Nick Hollon, Matthew Jones, R. J.R. Blair, Daniel S. Pine

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Context: Generalized social phobia (GSP) is characterized by fear/avoidance of social situations. Previous studies have examined the neural responses in GSP to one class of social stimuli, facial expressions. However, studies have not examined the neural response in GSP to another equally important class of social stimuli, the communication of praise or criticism. Objective: To examine the neural response to receipt of praise or criticism in GSP; specifically, to determine whether patients with GSP show an increased response to the receipt of both praise and criticism and whether self-relevance modulates this relationship. Design: Case-control study. Setting: Government clinical research institute. Participants; Unmedicated individuals with GSP (n= 17) and age-, IQ-, and sex-matched healthy comparison individuals (n=17). Main Outcome Measure: Blood oxygenation leveldependent signal, as measured via functional magnetic resonance imaging. During functional magnetic resonance imaging scans, individuals read positive (eg, You are beautiful), negative (eg, You are ugly), and neutral (eg, You are human) comments that could be either about the self or about somebody else (eg, He is beautiful). Results: Hypothesized significant group×valence×referent interactions were observed within regions of the medial prefrontal cortex and bilateral amygdala. In these regions, the patients with GSP showed significantly increased blood oxygenation level-dependent responses, relative to comparison individuals, to negative comments (criticism) referring to themselves. However, in contrast, there were no significant group differences with respect to negative comments referring to others or neutral or positive comments referring to self or others. Conclusions: These results implicate the medial prefrontal cortex, involved in the representation of the self, together with the amygdala, in the pathophysiology of GSP. Further, findings demonstrate a meaningful effect of psychological context on neural-circuitry hyperactivity in GSP.

Original languageEnglish (US)
Pages (from-to)1176-1184
Number of pages9
JournalArchives of general psychiatry
Volume65
Issue number10
DOIs
StatePublished - Oct 1 2008

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Blair, K., Geraci, M., Devido, J., McCaffrey, D., Chen, G., Vythilingam, M., Ng, P., Hollon, N., Jones, M., Blair, R. J. R., & Pine, D. S. (2008). Neural response to self- and other referential praise and criticism in generalized social phobia. Archives of general psychiatry, 65(10), 1176-1184. https://doi.org/10.1001/archpsyc.65.10.1176