Neural stem cells in the mammalian eye: Types and regulation

Iqbal Ahmad, Ani V. Das, Jackson James, Sumitra Bhattacharya, Xing Zhao

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number1
DOIs
StatePublished - Feb 2004

Keywords

  • Ciliary epithelium
  • Hedgehog
  • Notch
  • Retina
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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