Neural stem cells in the mammalian eye: Types and regulation

Iqbal Ahmad; Ani V. Das; Jackson James; Sumitra Bhattacharya; Xing Zhao

doi:10.1016/j.semcdb.2003.09.003

Neural stem cells in the mammalian eye: Types and regulation

Iqbal Ahmad, Ani V. Das, Jackson James, Sumitra Bhattacharya, Xing Zhao

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101 Scopus citations

Abstract

Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

Original language	English (US)
Pages (from-to)	53-62
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.semcdb.2003.09.003
State	Published - Feb 2004

Keywords

Ciliary epithelium
Hedgehog
Notch
Retina
Wnt

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2003.09.003

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title = "Neural stem cells in the mammalian eye: Types and regulation",

abstract = "Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.",

keywords = "Ciliary epithelium, Hedgehog, Notch, Retina, Wnt",

author = "Iqbal Ahmad and Das, {Ani V.} and Jackson James and Sumitra Bhattacharya and Xing Zhao",

note = "Funding Information: Thanks are due to Drs. Carl Camras, Graham Sharp, and Dave Crouse for critical reading of the manuscript and valuable suggestions, Dr. Mahendra Rao for his help with universal neural stem cell markers, and Dr. Jorg Rahenfuhrer for helping us analyze data related to transcription profiling. We would like to apologize to those whose works are not cited due to the space constraint. This work was supported by NEI, Nebraska Research Initiative and Research to Prevent Blindness.",

year = "2004",

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doi = "10.1016/j.semcdb.2003.09.003",

language = "English (US)",

volume = "15",

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T2 - Types and regulation

AU - Ahmad, Iqbal

AU - Das, Ani V.

AU - James, Jackson

AU - Bhattacharya, Sumitra

AU - Zhao, Xing

N1 - Funding Information: Thanks are due to Drs. Carl Camras, Graham Sharp, and Dave Crouse for critical reading of the manuscript and valuable suggestions, Dr. Mahendra Rao for his help with universal neural stem cell markers, and Dr. Jorg Rahenfuhrer for helping us analyze data related to transcription profiling. We would like to apologize to those whose works are not cited due to the space constraint. This work was supported by NEI, Nebraska Research Initiative and Research to Prevent Blindness.

PY - 2004/2

Y1 - 2004/2

N2 - Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

AB - Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

KW - Ciliary epithelium

KW - Hedgehog

KW - Notch

KW - Retina

KW - Wnt

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Neural stem cells in the mammalian eye: Types and regulation

Abstract

Keywords

ASJC Scopus subject areas

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