Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems

R. J.R. Blair, K. Veroude, J. K. Buitelaar

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems.

Original languageEnglish (US)
Pages (from-to)69-90
Number of pages22
JournalNeuroscience and Biobehavioral Reviews
Volume91
DOIs
StatePublished - Aug 2018

Keywords

  • Aggression
  • Callous unemotional traits
  • Conduct disorder
  • Decision-making
  • Empathy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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