TY - JOUR
T1 - Neurodegenerative disorders management
T2 - state-of-art and prospects of nano-biotechnology
AU - Kumar, Raj
AU - Aadil, Keshaw Ram
AU - Mondal, Kunal
AU - Mishra, Yogendra Kumar
AU - Oupicky, David
AU - Ramakrishna, Seeram
AU - Kaushik, Ajeet
N1 - Funding Information:
Raj Kumar acknowledges the Bar-Ilan University, Israel, University of Michigan, and University of Nebraska Medical Center, USA. K. R Aadil thanks to Science and Engineering Research Board (SERB), India, for awarding National Postdoctoral Fellowship (NPDF/2016/001156). Kunal Mondal gratefully acknowledges the Energy & Environment S & T at the Idaho National Laboratory, USA for their support.
Funding Information:
Raj Kumar acknowledges the Bar-Ilan University, Israel, University of Michigan, and University of Nebraska Medical Center, USA. K. R Aadil thanks to Science and Engineering Research Board (SERB), India, for awarding National Postdoctoral Fellowship (NPDF/2016/001156). Kunal Mondal gratefully acknowledges the Energy & Environment S & T at the Idaho National Laboratory, USA for their support.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Neurodegenerative disorders (NDs) are highly prevalent among the aging population. It affects primarily the central nervous system (CNS) but the effects are also observed in the peripheral nervous system. Neural degeneration is a progressive loss of structure and function of neurons, which may ultimately involve cell death. Such patients suffer from debilitating memory loss and altered motor coordination which bring up non-affordable and unavoidable socio-economic burdens. Due to the unavailability of specific therapeutics and diagnostics, the necessity to control or manage NDs raised the demand to investigate and develop efficient alternative approaches. Keeping trends and advancements in view, this report describes both state-of-the-art and challenges in nano-biotechnology-based approaches to manage NDs, toward personalized healthcare management. Sincere efforts are being made to customize nano-theragnostics to control: therapeutic cargo packaging, delivery to the brain, nanomedicine of higher efficacy, deep brain stimulation, implanted stimulation, and managing brain cell functioning. These advancements are useful to design future therapy based on the severity of the patient’s neurodegenerative disease. However, we observe a lack of knowledge shared among scientists of a variety of expertise to explore this multi-disciplinary research field for NDs management. Consequently, this review will provide a guideline platform that will be useful in developing novel smart nano-therapies by considering the aspects and advantages of nano-biotechnology to manage NDs in a personalized manner. Nano-biotechnology-based approaches have been proposed as effective and affordable alternatives at the clinical level due to recent advancements in nanotechnology-assisted theragnostics, targeted delivery, higher efficacy, and minimal side effects.
AB - Neurodegenerative disorders (NDs) are highly prevalent among the aging population. It affects primarily the central nervous system (CNS) but the effects are also observed in the peripheral nervous system. Neural degeneration is a progressive loss of structure and function of neurons, which may ultimately involve cell death. Such patients suffer from debilitating memory loss and altered motor coordination which bring up non-affordable and unavoidable socio-economic burdens. Due to the unavailability of specific therapeutics and diagnostics, the necessity to control or manage NDs raised the demand to investigate and develop efficient alternative approaches. Keeping trends and advancements in view, this report describes both state-of-the-art and challenges in nano-biotechnology-based approaches to manage NDs, toward personalized healthcare management. Sincere efforts are being made to customize nano-theragnostics to control: therapeutic cargo packaging, delivery to the brain, nanomedicine of higher efficacy, deep brain stimulation, implanted stimulation, and managing brain cell functioning. These advancements are useful to design future therapy based on the severity of the patient’s neurodegenerative disease. However, we observe a lack of knowledge shared among scientists of a variety of expertise to explore this multi-disciplinary research field for NDs management. Consequently, this review will provide a guideline platform that will be useful in developing novel smart nano-therapies by considering the aspects and advantages of nano-biotechnology to manage NDs in a personalized manner. Nano-biotechnology-based approaches have been proposed as effective and affordable alternatives at the clinical level due to recent advancements in nanotechnology-assisted theragnostics, targeted delivery, higher efficacy, and minimal side effects.
KW - Neurodegenerative disorders
KW - brain stimulation
KW - nano drug delivery system
KW - nano-therapies
KW - nanomedicine
KW - personalized health wellness
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U2 - 10.1080/07388551.2021.1993126
DO - 10.1080/07388551.2021.1993126
M3 - Review article
C2 - 34823433
AN - SCOPUS:85120829899
SN - 0738-8551
VL - 42
SP - 1180
EP - 1212
JO - Critical Reviews in Biotechnology
JF - Critical Reviews in Biotechnology
IS - 8
ER -