Neurodevelopment, GABA system dysfunction, and schizophrenia

Martin J. Schmidt, Karoly Mirnics

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.

Original languageEnglish (US)
Pages (from-to)190-206
Number of pages17
JournalNeuropsychopharmacology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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