TY - JOUR
T1 - Neurodevelopmental changes in social reinforcement processing
T2 - A functional magnetic resonance imaging study
AU - Hwang, Soonjo
AU - Meffert, Harma
AU - VanTieghem, Michelle R.
AU - White, Stuart F.
AU - Sinclair, Stephen
AU - Bookheimer, Susan Y.
AU - Blair, James
N1 - Funding Information:
This work was supported by the Intramural Research Program at the National Institute of Mental Health, National Institutes of Health under grant number 1-ZIA-MH002860-08 to Dr. Blair. None of the authors has conflict of interest in regard to this study.
Publisher Copyright:
© 2017, Korean College of Neuropsychopharmacology.
PY - 2017
Y1 - 2017
N2 - Objective: In the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement. Methods: Fifty-three healthy participants including 16 early adolescents (age, 10-15 years), 16 late adolescents (age, 15-18 years), and 21 young adults (age, 21-25 years) completed a social/non-social reward learning task while undergoing functional magnetic resonance imaging. Participants responded to fractal image stimuli and received social or non-social reward/non-rewards according to their accuracy. ANOVAs were conducted on both the blood oxygen level dependent response data and the product of a context-dependent psychophysiological interaction (gPPI) analysis involving ventromedial prefrontal cortex (vmPFC) and bilateral insula cortices as seed regions. Results: Early adolescents showed significantly increased activation in the amygdala and anterior insula cortex in response to non-social monetary rewards relative to both social reward/non-reward and monetary non-rewards compared to late adolescents and young adults. In addition, early adolescents showed significantly more positive connectivity between the vmPFC/bilateral insula cortices seeds and other regions implicated in reinforcement processing (the amygdala, posterior cingulate cortex, insula cortex, and lentiform nucleus) in response to non-reward and especially social non-reward, compared to late adolescents and young adults. Conclusion: It appears that early adolescence may be marked by: (i) a selective increase in responsiveness to non-social, relative to social, rewards; and (ii) enhanced, integrated functioning of reinforcement circuitry for non-reward, and in particular, with respect to posterior cingulate and insula cortices, for social non-reward.
AB - Objective: In the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement. Methods: Fifty-three healthy participants including 16 early adolescents (age, 10-15 years), 16 late adolescents (age, 15-18 years), and 21 young adults (age, 21-25 years) completed a social/non-social reward learning task while undergoing functional magnetic resonance imaging. Participants responded to fractal image stimuli and received social or non-social reward/non-rewards according to their accuracy. ANOVAs were conducted on both the blood oxygen level dependent response data and the product of a context-dependent psychophysiological interaction (gPPI) analysis involving ventromedial prefrontal cortex (vmPFC) and bilateral insula cortices as seed regions. Results: Early adolescents showed significantly increased activation in the amygdala and anterior insula cortex in response to non-social monetary rewards relative to both social reward/non-reward and monetary non-rewards compared to late adolescents and young adults. In addition, early adolescents showed significantly more positive connectivity between the vmPFC/bilateral insula cortices seeds and other regions implicated in reinforcement processing (the amygdala, posterior cingulate cortex, insula cortex, and lentiform nucleus) in response to non-reward and especially social non-reward, compared to late adolescents and young adults. Conclusion: It appears that early adolescence may be marked by: (i) a selective increase in responsiveness to non-social, relative to social, rewards; and (ii) enhanced, integrated functioning of reinforcement circuitry for non-reward, and in particular, with respect to posterior cingulate and insula cortices, for social non-reward.
KW - Amygdala
KW - Anterior insula
KW - Context-dependent psychophysiological interaction
KW - Functional magnetic resonance imaging
KW - Social reward
KW - Ventro-medial prefrontal cortex
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U2 - 10.9758/cpn.2017.15.4.369
DO - 10.9758/cpn.2017.15.4.369
M3 - Article
C2 - 29073749
AN - SCOPUS:85032722348
VL - 15
SP - 369
EP - 381
JO - Clinical Psychopharmacology and Neuroscience
JF - Clinical Psychopharmacology and Neuroscience
SN - 1738-1088
IS - 4
ER -