Neurohumoral Stimulation

Irving H. Zucker; Kaushik P. Patel; Harold D. Schultz

doi:10.1016/j.hfc.2011.08.007

Neurohumoral Stimulation

Irving H. Zucker, Kaushik P. Patel, Harold D. Schultz

Research output: Contribution to journal › Review article

72 Scopus citations

Abstract

The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

Original language	English (US)
Pages (from-to)	87-99
Number of pages	13
Journal	Heart Failure Clinics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.hfc.2011.08.007
State	Published - Jan 2012

Keywords

Baroreflex
Carotid body chemoreflex
Chronic heart failure
Neurohumoral activation
Sympathoexcitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Zucker, I. H., Patel, K. P., & Schultz, H. D. (2012). Neurohumoral Stimulation. Heart Failure Clinics, 8(1), 87-99. https://doi.org/10.1016/j.hfc.2011.08.007

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