Neurohumoral Stimulation

Irving H. Zucker; Kaushik P. Patel; Harold D. Schultz

doi:10.1016/j.hfc.2011.08.007

Neurohumoral Stimulation

Irving H. Zucker, Kaushik P. Patel, Harold D. Schultz

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

Original language	English (US)
Pages (from-to)	87-99
Number of pages	13
Journal	Heart Failure Clinics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.hfc.2011.08.007
State	Published - Jan 2012

Keywords

Baroreflex
Carotid body chemoreflex
Chronic heart failure
Neurohumoral activation
Sympathoexcitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.hfc.2011.08.007

Cite this

@article{884d6172da544532afc2159809b71e52,

title = "Neurohumoral Stimulation",

abstract = "The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.",

keywords = "Baroreflex, Carotid body chemoreflex, Chronic heart failure, Neurohumoral activation, Sympathoexcitation",

author = "Zucker, {Irving H.} and Patel, {Kaushik P.} and Schultz, {Harold D.}",

note = "Funding Information: Some of the work shown in this paper was supported by a grant from the NIH ; PO-1 HL62222 . ",

year = "2012",

month = jan,

doi = "10.1016/j.hfc.2011.08.007",

language = "English (US)",

volume = "8",

pages = "87--99",

journal = "Heart Failure Clinics",

issn = "1551-7136",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Neurohumoral Stimulation

AU - Zucker, Irving H.

AU - Patel, Kaushik P.

AU - Schultz, Harold D.

N1 - Funding Information: Some of the work shown in this paper was supported by a grant from the NIH ; PO-1 HL62222 .

PY - 2012/1

Y1 - 2012/1

N2 - The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

AB - The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

KW - Baroreflex

KW - Carotid body chemoreflex

KW - Chronic heart failure

KW - Neurohumoral activation

KW - Sympathoexcitation

UR - http://www.scopus.com/inward/record.url?scp=82955246195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955246195&partnerID=8YFLogxK

U2 - 10.1016/j.hfc.2011.08.007

DO - 10.1016/j.hfc.2011.08.007

M3 - Review article

C2 - 22108729

AN - SCOPUS:82955246195

VL - 8

SP - 87

EP - 99

JO - Heart Failure Clinics

JF - Heart Failure Clinics

SN - 1551-7136

IS - 1

ER -

Neurohumoral Stimulation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this