Neuromagnetic biomarkers of visuocortical development in healthy children

Yangmei Chen, Jing Xiang, Elijah G. Kirtman, Yingying Wang, Rupesh Kotecha, Yang Liu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children. Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks. Results: Three response peaks were identified at 77 ± 8. ms (M75), 111 ± 9. ms (M100) and 150 ± 11. ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01). Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children. Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.

Original languageEnglish (US)
Pages (from-to)1555-1562
Number of pages8
JournalClinical Neurophysiology
Issue number9
StatePublished - Sep 2010


  • Brain
  • Development
  • Magnetoencephalography
  • Visual cortex
  • Visual evoked magnetic fields

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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