Neuromagnetic biomarkers of visuocortical development in healthy children

Yangmei Chen; Jing Xiang; Elijah G. Kirtman; Yingying Wang; Rupesh Kotecha; Yang Liu

doi:10.1016/j.clinph.2010.03.029

Neuromagnetic biomarkers of visuocortical development in healthy children

Yangmei Chen, Jing Xiang, Elijah G. Kirtman, Yingying Wang, Rupesh Kotecha, Yang Liu

Special Education and Communication Disorders

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children. Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks. Results: Three response peaks were identified at 77 ± 8. ms (M75), 111 ± 9. ms (M100) and 150 ± 11. ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01). Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children. Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.

Original language	English (US)
Pages (from-to)	1555-1562
Number of pages	8
Journal	Clinical Neurophysiology
Volume	121
Issue number	9
DOIs	https://doi.org/10.1016/j.clinph.2010.03.029
State	Published - Sep 2010

Keywords

Brain
Development
Magnetoencephalography
Visual cortex
Visual evoked magnetic fields

ASJC Scopus subject areas

Sensory Systems
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.clinph.2010.03.029

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title = "Neuromagnetic biomarkers of visuocortical development in healthy children",

abstract = "Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children. Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks. Results: Three response peaks were identified at 77 ± 8. ms (M75), 111 ± 9. ms (M100) and 150 ± 11. ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01). Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children. Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.",

keywords = "Brain, Development, Magnetoencephalography, Visual cortex, Visual evoked magnetic fields",

author = "Yangmei Chen and Jing Xiang and Kirtman, {Elijah G.} and Yingying Wang and Rupesh Kotecha and Yang Liu",

note = "Funding Information: This study was supported by a Trustee Grant to Dr. Jing Xiang from Cincinnati Children{\textquoteright}s Hospital Medical Center, Cincinnati, OH, USA .",

year = "2010",

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doi = "10.1016/j.clinph.2010.03.029",

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AU - Chen, Yangmei

AU - Xiang, Jing

AU - Kirtman, Elijah G.

AU - Wang, Yingying

AU - Kotecha, Rupesh

AU - Liu, Yang

N1 - Funding Information: This study was supported by a Trustee Grant to Dr. Jing Xiang from Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA .

PY - 2010/9

Y1 - 2010/9

N2 - Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children. Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks. Results: Three response peaks were identified at 77 ± 8. ms (M75), 111 ± 9. ms (M100) and 150 ± 11. ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01). Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children. Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.

AB - Objective: The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children. Methods: Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks. Results: Three response peaks were identified at 77 ± 8. ms (M75), 111 ± 9. ms (M100) and 150 ± 11. ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01). Conclusions: The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children. Significance: The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.

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KW - Development

KW - Magnetoencephalography

KW - Visual cortex

KW - Visual evoked magnetic fields

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Neuromagnetic biomarkers of visuocortical development in healthy children

Abstract

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ASJC Scopus subject areas

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