TY - JOUR
T1 - Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease
AU - Heinrichs-Graham, Elizabeth
AU - Wilson, Tony W.
AU - Santamaria, Pamela M.
AU - Heithoff, Sheila K.
AU - Torres-Russotto, Diego
AU - Hutter-Saunders, Jessica A.L.
AU - Estes, Katherine A.
AU - Meza, Jane L.
AU - Mosley, R. L.
AU - Gendelman, Howard E.
N1 - Funding Information:
This work was supported by an Innovation grant from the Michael J. Fox Foundation for Parkinson’s Research, the Fran-cine and Louis Blumkin Foundation, the Community Neuroscience Pride of Nebraska Research Initiative, the Carol Swarts, M.D., Laboratory of Emerging Neuroscience Research, the Alan Baer Charitable Trust, Schumacher Foundation and National Institutes of Health grants P20 DA026146, 5P01 DA028555-02, R01 NS36126, P01 NS31492, 2R01 NS034239, P20 RR15635, P01 MH64570, P01 NS43985, and R01 NS070190, and by the Hattie B. Munroe Foundation. The Center for Magnetoencephalography at the University of Nebraska Medical Center was founded through an endowment fund from an anonymous donor. Funding to pay the Open Access publication charges for this article was provided by the University of Nebraska Medical Center Research Development Funds.
PY - 2014/10
Y1 - 2014/10
N2 - Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.
AB - Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.
KW - Cortex
KW - MEG
KW - Magnetoencephalography
KW - Motor control
KW - Oscillations
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U2 - 10.1093/cercor/bht121
DO - 10.1093/cercor/bht121
M3 - Article
C2 - 23645717
AN - SCOPUS:84908331446
VL - 24
SP - 2669
EP - 2678
JO - Cerebral cortex (New York, N.Y. : 1991)
JF - Cerebral cortex (New York, N.Y. : 1991)
SN - 1047-3211
IS - 10
ER -