Neuronal failure in Alzheimer's disease: A view through the oxidative stress looking-glass

David J. Bonda, Xinglong Wang, Hyoung Gon Lee, Mark A. Smith, George Perry, Xiongwei Zhu

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalNeuroscience Bulletin
Volume30
Issue number2
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Alzheimer's disease
  • amyloid-beta
  • free radicals
  • mitochondria
  • mitochondrial dynamics
  • oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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