TY - JOUR
T1 - Neuropathogenesis of Central Nervous System HIV infection
AU - McGuire, Jennifer L.
AU - Goodkin, Karl
AU - Douglas, Steven D.
PY - 2013/5
Y1 - 2013/5
N2 - Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common and devastating complication of HIV infection, affecting up to 47% of HIV-seropositive individuals in the combination antiretroviral (cART) era.1 Because HAND independently predicts non-central nervous system (CNS) morbidity and overall HIV mortality,2 there is an urgent need to better understand these disorders to develop therapeutic approaches. However, HIV neuropathogenesis, HAND, and its related neuropathology, HIV-encephalitis (HIVE), are complex and incompletely understood. This article describes the current understanding of the basic virology and neuropathogenesis of HIV that contribute to HAND and HIVE.
AB - Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common and devastating complication of HIV infection, affecting up to 47% of HIV-seropositive individuals in the combination antiretroviral (cART) era.1 Because HAND independently predicts non-central nervous system (CNS) morbidity and overall HIV mortality,2 there is an urgent need to better understand these disorders to develop therapeutic approaches. However, HIV neuropathogenesis, HAND, and its related neuropathology, HIV-encephalitis (HIVE), are complex and incompletely understood. This article describes the current understanding of the basic virology and neuropathogenesis of HIV that contribute to HAND and HIVE.
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U2 - 10.3928/00485713-20130503-05
DO - 10.3928/00485713-20130503-05
M3 - Article
AN - SCOPUS:84878947352
VL - 43
SP - 212
EP - 216
JO - Psychiatric Annals
JF - Psychiatric Annals
SN - 0048-5713
IS - 5
ER -