Neuropathogenesis of Central Nervous System HIV infection

Jennifer L. McGuire, Karl Goodkin, Steven D. Douglas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common and devastating complication of HIV infection, affecting up to 47% of HIV-seropositive individuals in the combination antiretroviral (cART) era.1 Because HAND independently predicts non-central nervous system (CNS) morbidity and overall HIV mortality,2 there is an urgent need to better understand these disorders to develop therapeutic approaches. However, HIV neuropathogenesis, HAND, and its related neuropathology, HIV-encephalitis (HIVE), are complex and incompletely understood. This article describes the current understanding of the basic virology and neuropathogenesis of HIV that contribute to HAND and HIVE.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalPsychiatric Annals
Issue number5
StatePublished - May 2013
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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