Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway

Joel R. Frandsen, Prabagaran Narayanasamy

Research output: Contribution to journalShort surveypeer-review

44 Scopus citations

Abstract

The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection. Excessive concentrations of methylglyoxal have deleterious effects on cells, leading to increased levels of inflammation and oxidative stress. Neurodegenerative diseases – including Alzheimer's, Parkinson's, Aging and Autism Spectrum Disorder – are often induced or exacerbated by accumulation of methylglyoxal. Antioxidant compounds possess several distinct mechanisms that enhance the glyoxalase pathway and function as neuroprotectants. Flavonoids are well-researched secondary plant metabolites that appear to be effective in reducing levels of oxidative stress and inflammation in neural cells. Novel flavonoids could be designed, synthesized and tested to protect against neurodegenerative diseases through regulating the glyoxalase pathway.

Original languageEnglish (US)
Pages (from-to)465-473
Number of pages9
JournalRedox Biology
Volume14
DOIs
StatePublished - Apr 2018

Keywords

  • Antioxidant
  • Detoxification
  • Flavonoid
  • Glyoxalase pathway
  • Neurodegenerative disease
  • Neuron
  • Neurons viable
  • Neuroprotection

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

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