Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases

Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceedingChapter


The interplay between innate and adaptive immunity strongly influences the pathobiology of neurodegenerative, neuroinflammatory, and neuroinfectious diseases. Specific and sustained immune responses can induce disease by affecting neuronal injury and death. Disease progression parallels glial proliferation, proinflammatory cytokine production and adaptive immune responses against the inciting misfolded protein or infectious agent. All affect neuronal demise. Neuroprotective immune transformation remains a therapeutic avenue being developed by several research groups towards the shared goal of sustaining a nourishing brain microenvironment.

Original languageEnglish (US)
Title of host publicationAdvanced Concepts in Human Immunology
Subtitle of host publicationProspects for Disease Control
PublisherSpringer International Publishing
Number of pages36
ISBN (Electronic)9783030339463
ISBN (Print)9783030339456
StatePublished - Jan 1 2020


  • Adaptive immunity
  • Alzheimer’s disease
  • Human immunodeficiency virus
  • Innate immunity
  • Neurodegeneration
  • Neuroprotection
  • Parkinson’s disease

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


Dive into the research topics of 'Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases'. Together they form a unique fingerprint.

Cite this