Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases

Katherine E. Olson; R. Lee Mosley; Howard E. Gendelman

doi:10.1007/978-3-030-33946-3_8

Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases

Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The interplay between innate and adaptive immunity strongly influences the pathobiology of neurodegenerative, neuroinflammatory, and neuroinfectious diseases. Specific and sustained immune responses can induce disease by affecting neuronal injury and death. Disease progression parallels glial proliferation, proinflammatory cytokine production and adaptive immune responses against the inciting misfolded protein or infectious agent. All affect neuronal demise. Neuroprotective immune transformation remains a therapeutic avenue being developed by several research groups towards the shared goal of sustaining a nourishing brain microenvironment.

Original language	English (US)
Title of host publication	Advanced Concepts in Human Immunology
Subtitle of host publication	Prospects for Disease Control
Publisher	Springer International Publishing
Pages	335-370
Number of pages	36
ISBN (Electronic)	9783030339463
ISBN (Print)	9783030339456
DOIs	https://doi.org/10.1007/978-3-030-33946-3_8
State	Published - Jan 1 2020

Keywords

Adaptive immunity
Alzheimer’s disease
Human immunodeficiency virus
Innate immunity
Neurodegeneration
Neuroprotection
Parkinson’s disease

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1007/978-3-030-33946-3_8

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abstract = "The interplay between innate and adaptive immunity strongly influences the pathobiology of neurodegenerative, neuroinflammatory, and neuroinfectious diseases. Specific and sustained immune responses can induce disease by affecting neuronal injury and death. Disease progression parallels glial proliferation, proinflammatory cytokine production and adaptive immune responses against the inciting misfolded protein or infectious agent. All affect neuronal demise. Neuroprotective immune transformation remains a therapeutic avenue being developed by several research groups towards the shared goal of sustaining a nourishing brain microenvironment.",

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AU - Mosley, R. Lee

AU - Gendelman, Howard E.

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N2 - The interplay between innate and adaptive immunity strongly influences the pathobiology of neurodegenerative, neuroinflammatory, and neuroinfectious diseases. Specific and sustained immune responses can induce disease by affecting neuronal injury and death. Disease progression parallels glial proliferation, proinflammatory cytokine production and adaptive immune responses against the inciting misfolded protein or infectious agent. All affect neuronal demise. Neuroprotective immune transformation remains a therapeutic avenue being developed by several research groups towards the shared goal of sustaining a nourishing brain microenvironment.

AB - The interplay between innate and adaptive immunity strongly influences the pathobiology of neurodegenerative, neuroinflammatory, and neuroinfectious diseases. Specific and sustained immune responses can induce disease by affecting neuronal injury and death. Disease progression parallels glial proliferation, proinflammatory cytokine production and adaptive immune responses against the inciting misfolded protein or infectious agent. All affect neuronal demise. Neuroprotective immune transformation remains a therapeutic avenue being developed by several research groups towards the shared goal of sustaining a nourishing brain microenvironment.

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KW - Alzheimer’s disease

KW - Human immunodeficiency virus

KW - Innate immunity

KW - Neurodegeneration

KW - Neuroprotection

KW - Parkinson’s disease

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ER -

Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases

Abstract

Keywords

ASJC Scopus subject areas

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