Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine

M. J. Hepburn, M. G. Kortepeter, P. R. Pittman, E. F. Boudreau, J. A. Mangiafico, P. A. Buck, S. L. Norris, E. L. Anderson

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


A retrospective review was conducted of yellow fever vaccination among laboratory workers receiving annual serologic assessment to determine the initial and long-term response after boosting. Patients were divided into three groups based on pre-vaccination serology: Group 1, 1:10; Group 2, 1:20-1:40 and Group 3, >1:40. The percent with ≥four-fold increase in titers after booster vaccination were: 78% (646/829, Group 1), 65% (79/121, Group 2) and 10% (8/79, Group 3) (p < 0.0001). The median times to titer failure (<1:40) were 798 days (Group 1), 3340 days (Group 2) and 7709 days (Group 3) (p < 0.0001). Pre-vaccination serology influenced the initial and long-term response to yellow fever booster vaccination.

Original languageEnglish (US)
Pages (from-to)2843-2849
Number of pages7
Issue number15
StatePublished - Apr 5 2006
Externally publishedYes


  • Booster
  • Neutralizing antibody
  • Yellow fever vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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