Neutrophil roles in left ventricular remodeling following myocardial infarction

Yonggang Ma, Andriy Yabluchanskiy, Merry L. Lindsey

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Polymorphonuclear granulocytes (PMNs; neutrophils) serve as key effector cells in the innate immune system and provide the first line of defense against invading microorganisms. In addition to producing inflammatory cytokines and chemokines and undergoing a respiratory burst that stimulates the release of reactive oxygen species, PMNs also degranulate to release components that kill pathogens. Recently, neutrophil extracellular traps have been shown to be an alternative way to trap microorganisms and contain infection. PMN-derived granule components are also involved in multiple non-infectious inflammatory processes, including the response to myocardial infarction (MI). In this review, we will discuss the biological characteristics, recruitment, activation, and removal of PMNs, as well as the roles of PMN-derived granule proteins in inflammation and innate immunity, focusing on the MI setting when applicable. We also discuss future perspectives that will direct research in PMN biology.

Original languageEnglish (US)
Article number11
JournalFibrogenesis and Tissue Repair
Volume6
Issue number1
DOIs
StatePublished - Jun 3 2013

Keywords

  • Degranulation
  • Inflammation
  • Innate immunity
  • Matrix metalloproteinases
  • Myocardial infarction
  • PMNs

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Rheumatology
  • Hepatology
  • Dermatology
  • Gastroenterology

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