TY - JOUR
T1 - Neutrophil roles in left ventricular remodeling following myocardial infarction
AU - Ma, Yonggang
AU - Yabluchanskiy, Andriy
AU - Lindsey, Merry L.
N1 - Funding Information:
We acknowledge support from NIH/NHLBI HHSN 268201000036C (N01-HV-00244) for the San Antonio Cardiovascular Proteomics Center and R01 HL075360, and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5I01BX000505 to MLL.
PY - 2013/6/3
Y1 - 2013/6/3
N2 - Polymorphonuclear granulocytes (PMNs; neutrophils) serve as key effector cells in the innate immune system and provide the first line of defense against invading microorganisms. In addition to producing inflammatory cytokines and chemokines and undergoing a respiratory burst that stimulates the release of reactive oxygen species, PMNs also degranulate to release components that kill pathogens. Recently, neutrophil extracellular traps have been shown to be an alternative way to trap microorganisms and contain infection. PMN-derived granule components are also involved in multiple non-infectious inflammatory processes, including the response to myocardial infarction (MI). In this review, we will discuss the biological characteristics, recruitment, activation, and removal of PMNs, as well as the roles of PMN-derived granule proteins in inflammation and innate immunity, focusing on the MI setting when applicable. We also discuss future perspectives that will direct research in PMN biology.
AB - Polymorphonuclear granulocytes (PMNs; neutrophils) serve as key effector cells in the innate immune system and provide the first line of defense against invading microorganisms. In addition to producing inflammatory cytokines and chemokines and undergoing a respiratory burst that stimulates the release of reactive oxygen species, PMNs also degranulate to release components that kill pathogens. Recently, neutrophil extracellular traps have been shown to be an alternative way to trap microorganisms and contain infection. PMN-derived granule components are also involved in multiple non-infectious inflammatory processes, including the response to myocardial infarction (MI). In this review, we will discuss the biological characteristics, recruitment, activation, and removal of PMNs, as well as the roles of PMN-derived granule proteins in inflammation and innate immunity, focusing on the MI setting when applicable. We also discuss future perspectives that will direct research in PMN biology.
KW - Degranulation
KW - Inflammation
KW - Innate immunity
KW - Matrix metalloproteinases
KW - Myocardial infarction
KW - PMNs
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U2 - 10.1186/1755-1536-6-11
DO - 10.1186/1755-1536-6-11
M3 - Review article
C2 - 23731794
AN - SCOPUS:84878353026
SN - 1755-1536
VL - 6
JO - Fibrogenesis and Tissue Repair
JF - Fibrogenesis and Tissue Repair
IS - 1
M1 - 11
ER -