New Applications in Echocardiography for Ultrasound Contrast Agents in the 21st Century

Thomas R. Porter, Steve B. Feinstein, Folkert J. Ten Cate, Annemien E. van den Bosch

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Contrast echocardiography microbubbles are ultrasound-enhancing agents that were originally designed to help improve endocardial border definition, known as left ventricle opacification, and to enhance Doppler signals. Over time, contrast microbubbles are used to assess myocardial perfusion because they travel through the capillaries of the cardiac circulation. Current research provides good evidence that myocardial perfusion echocardiography improves comprehensive echocardiographic evaluations of ischemic heart disease. The approval of regulatory authorities and the availability of quantitative operator-independent analysis software will hopefully prompt physicians and sonographers to implement myocardial perfusion echocardiography into the daily workflow of echo laboratories. New diagnostic and therapeutic applications will result in improved patient care, especially in the area of sonothrombolysis, where preliminary data have already shown utilization in ST elevation myocardial infarction, improving left ventricular systolic function and reducing the need for implantable defibrillators at 6-mo follow-up. This review gives an overview of the applications of myocardial perfusion imaging with ultrasound. Each cited study had institutional review board/institutional animal care and use approval.

Original languageEnglish (US)
Pages (from-to)1071-1081
Number of pages11
JournalUltrasound in Medicine and Biology
Issue number5
StatePublished - May 2020


  • Contrast agents
  • Myocardial perfusion
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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