New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease

Xinghui Sun, Edward N. Harris

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The liver is the central metabolic hub for carbohydrate, lipid, and protein metabolism. It is composed of four major types of cells, including hepatocytes, endothelial cells (ECs), Kupffer cells, and stellate cells. Hepatic ECs are highly heterogeneous in both mice and humans, representing the second largest population of cells in liver. The majority of them line hepatic sinusoids known as liver sinusoidal ECs (LSECs). The structure and biology of LSECs and their roles in physiology and liver disease were reviewed recently. Here, we do not give a comprehensive review of LSEC structure, function, or pathophysiology. Instead, we focus on the recent progress in LSEC research and other hepatic ECs in physiology and nonalcoholic fatty liver disease and other hepatic fibrosis-related conditions. We discuss several current areas of interest, including capillarization, scavenger function, autophagy, cellular senescence, paracrine effects, and mechanotransduction. In addition, we summarize the strengths and weaknesses of evidence for the potential role of endothelial-to-mesenchymal transition in liver fibrosis.

Original languageEnglish (US)
Pages (from-to)C1200-C1213
JournalAmerican Journal of Physiology - Cell Physiology
Issue number6
StatePublished - Jun 2020


  • Autophagy
  • Cellular senescence
  • Fibrosis
  • Hepatic endothelium
  • LSECs
  • Scavenger function

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


Dive into the research topics of 'New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease'. Together they form a unique fingerprint.

Cite this